Michael R. Baldwin Joins MMI Faculty
Posted by: admin
Welcome to Dr. Michael R. Baldwin as the newest member of the MMI faculty.
Dr. Baldwin trained in the laboratory of Alistair Lax, Ph. D. at King’s College, London, where his studies focused on the mode of action of Pasteurella multocida toxin (PMT) using biochemical and cell biological approaches.
He then joined the laboratory of Prof. Joseph Barbieri at the Medical College of Wisconsin as a postdoctoral fellow. There he investigated the mode of action of botulinum neurotoxins (BoNTs) by developing an E. coli-based expression system that has allowed structure-function studies of the BoNT proteins. His work resulted in the identification of arginine hydroxamate as a small molecule inhibitor of BoNT/A, in the first co-crystal of BoNT/A bound to a catalytic inhibitor, in the generation of a heptavalent subunit vaccine against botulism, and in identification of a cellular receptor complex for BoNTs.